Zuckerberg shared a series of snaps on Instagram of him and his wife donning sparkly attire as they smiled, kissed and hit the dance floor.
"Disco queen wanted a party," Zuckerberg captioned the post.
This comes weeks after he designed a custom Porsche minivan – the first ever to hit the road – for his wife, Priscilla Chan.
"Priscilla wanted a minivan, so I've been designing something I'm pretty sure should exist," he wrote as he shared a photo of the customised car alongside his.
Before that, he had a statue of her made in their backyard.
Zuckerberg met Chan at a house party during her freshman year at Harvard in 2003.
They wed in May 2012 - the day after Facebook's IPO made him a multi-billionaire.
The couple, who own homes in California and Hawaii, are parents to three daughters; eight year-old Maxima, six year-old August and Aurelia, who is 19 months-old.
Chan graduated Harvard with a bachelor's degree in biology and worked as a teacher for a year.
She went back to college in 2008 to train as a pediatrician and completed her residency in 2015.
